手機版
化工儀器網手機版
化工儀器網小程序
官方微信
公眾號：chem17
掃碼關注視頻號
| Synonyms : | Shh, HHG-1 | ||||||||||||||||
| Description : | Hedgehog （Hh） proteins are widely distributed throughout the animal kingdom and play important regulatory roles in various development processes. The three known mammalian Hh proteins, Sonic （Shh）, Desert （Dhh） and Indian （Ihh） are structurally related and share a high degree of amino acid sequence identity （e.g. Shh and Ihh are 93 % identical）. Although, Hh proteins have unique expression patterns and distinct biological roles within their respective regions of secretion, they signal through the same Patched （Ptc）/Smoothened （Smo） receptor complex, activate the same intracellular signaling pathway, and can substitute for each other in experimental systems. The mature biologically active form of Hh molecules is produced by autocatalytic cleavage of their precursor proteins and corresponds to approximay the N-terminal half of the precursor molecule. Recombinant human Shh is a 20.6 kDa protein consisting of 174 amino acid residues, which correspond to the active N-terminal portion of the Shh precursor. | ||||||||||||||||
| Catalog #: | 100-45B | ||||||||||||||||
| Source : | （BTI-Tn-5B1-4） High-5 Insect Cells* | ||||||||||||||||
| Stability : | The lyophilized protein is stable for at least 2 years from date of receipt at -200C. Reconstituted Shh is stable for at least 3 months when stored in working aliquots with a carrier protein at -200C. Avoid repeated freeze/thaw cycles.3 | ||||||||||||||||
| Purity : | Greater than 98% by SDS-PAGE gel and HPLC analyses. | ||||||||||||||||
| Endotoxin Level : | Endotoxin level is less than 0.1 ng per μg （1EU/μg）. | ||||||||||||||||
| Biological Activity : | Determined by its ability to induce alkaline phosphatase production by C3H/10T1/2 （CCL-226） cells. The expected ED50 for this effect is 0.8-1.0 μg/ml. | ||||||||||||||||
| PubMed Link : | Sonic+AND+Hedgehog | ||||||||||||||||
| Country of Origin : | USA | ||||||||||||||||
| | | ||||||||||||||||
| |
| ||||||||||||||||
相關產品
免責聲明
- 凡本網注明“來源：化工儀器網”的所有作品，均為浙江興旺寶明通網絡有限公司-化工儀器網合法擁有版權或有權使用的作品，未經本網授權不得轉載、摘編或利用其它方式使用上述作品。已經本網授權使用作品的，應在授權范圍內使用，并注明“來源：化工儀器網”。違反上述聲明者，本網將追究其相關法律責任。
- 本網轉載并注明自其他來源（非化工儀器網）的作品，目的在于傳遞更多信息，并不代表本網贊同其觀點和對其真實性負責，不承擔此類作品侵權行為的直接責任及連帶責任。其他媒體、網站或個人從本網轉載時，必須保留本網注明的作品第一來源，并自負版權等法律責任。
- 如涉及作品內容、版權等問題，請在作品發(fā)表之日起一周內與本網聯(lián)系，否則視為放棄相關權利。
采購中心