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探討石化生產(chǎn)中產(chǎn)生的聚乙烯、聚丙烯、尼龍六六鹽 3種有機(jī)粉塵的危害性及預(yù)防措施。方法　生產(chǎn)現(xiàn)場(chǎng)勞動(dòng)衛(wèi)生學(xué)調(diào)查 ,粉塵的毒性及對(duì)大鼠肺的致纖維化作用動(dòng)物實(shí)驗(yàn)。結(jié)果　作業(yè)場(chǎng)所粉塵濃度聚乙烯 14 2mg/m3 ,聚丙烯 4 1 6mg/m3 ,尼龍六六鹽 2 5 0mg/m3 ;3種有機(jī)粉塵LD50 >15 0 0 0～30 0 0 0mg/kg;大鼠支氣管染塵后經(jīng) 1～ 18個(gè)月觀察 ,發(fā)現(xiàn)實(shí)驗(yàn)動(dòng)物肺組織切片上可見(jiàn)網(wǎng)織纖維增生和少量膠原纖維 ,染塵后的體外細(xì)胞培養(yǎng)液中巨噬細(xì)胞著色率和乳酸脫氫酶活性單位顯著高于正常對(duì)照組 ,但低于石英粉塵對(duì)照組。結(jié)論 3種有機(jī)粉塵雖均屬無(wú)毒物質(zhì) ,但據(jù)體外肺巨噬細(xì)胞實(shí)驗(yàn)結(jié)果對(duì)肺巨噬細(xì)胞有輕微毒性 ,對(duì)大鼠肺有輕度致纖維化作用。生產(chǎn)現(xiàn)場(chǎng)粉塵污染嚴(yán)重 ,長(zhǎng)期接觸可能造成職業(yè)危害 ,應(yīng)積極采取預(yù)防措施
    Objective To investigate the hazardous effects and preventive measures of organic dusts of polyethylene,polypropylene and Nylon 66 salt.Methods Field survey and animal experiments were conducted.Results The dust concentrations of polyethylene,polypropylene and Nylon 66 salt were 14 2,41 6 and 250 0 mg/m 3 respectively.LD 50 of these three dusts was 15 000 ～ 30 000 mg/m 3 .After inhalation exposure of the dusts and sacrificed 18 months later,it was found that there were reticular fibers p...