SM-102

MCE 國(guó)際站：SM-102

CAS：2089251-47-6

品牌：MedChemExpress (MCE)

存儲(chǔ)條件：Pure form: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：SM-102 是一種可電離的氨基脂質(zhì)，可用于形成脂質(zhì)納米粒子 (LNPs)^[1]。 SM-102 具有開(kāi)發(fā)用于遞送基于 mRNA 的疫苗的脂質(zhì)納米顆粒的潛力^[2]。

體外：SM-102 (100-300 µM, 1 分鐘) 濃度依賴(lài)性地抑制 GH3 細(xì)胞中 Erg 介導(dǎo)的 K+ 電流 (IK(erg)) 幅度[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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研究領(lǐng)域：Metabolic Enzyme/Protease

作用靶點(diǎn)：Liposome

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參考文獻(xiàn)：

[1]. Staci Sabnis, et al. A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates. Mol Ther. 2018 Jun 6;26(6):1509-1519.

[2]. Escalona-Rayo O, et al. In vitro and in vivo evaluation of clinically-approved ionizable cationic lipids shows divergent results between mRNA transfection and vaccine efficacy. Biomed Pharmacother. 2023 Sep;165:115065.

[3]. Cho HY, et al. Effective Perturbations on the Amplitude and Hysteresis of Erg-Mediated Potassium Current Caused by 1-Octylnonyl 8-[(2-hydroxyethyl)[6-oxo-6(undecyloxy)hexyl]amino]-octanoate (SM-102), a Cationic Lipid. Biomedicines. 2021 Oct 1;9(10):1367.