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α2-Macroglobulin (human plasma), (purified) 返回列表頁

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參考價: ￥ 1425

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品牌Enzo Life Sciences

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產(chǎn)品簡介

供貨周期	兩周	規(guī)格	1*1mg
貨號	BML-SE502-0001	應(yīng)用領(lǐng)域	生物產(chǎn)業(yè)
主要用途	科研

α2-Macroglobulin (human plasma), (purified)
品牌： ENZO產(chǎn)品貨號： BML-SE502-0001規(guī)格： 1*1mg
如需購買該產(chǎn)品或咨詢其他問題，請聯(lián)系ENZO一級代理商-欣博盛生物

詳情介紹

α2-Macroglobulin (human plasma), (purified)

Product Details

MW:	725 kDa

Source:	Isolated from human plasma that is tested to be negative for HbsAg, anti-HBc, anti-HCV, and anti-HIV-1 and -2.

UniProt ID:	P01023

Shipping:	Shipped on Blue Ice

Long Term Storage:	-20°C

Scientific Background:	In addition to binding TGF-β and β-amyloid, α2-macroglobulin covalently binds and inhibits a wide range of proteases, including ADAMs, calpains, cathepsins, chymase, clotting factors, kallikreins, MMPs, neutrophil elastase, and proteinase 3. It also plays a role in the innate immune system, inhibiting parasitic proteases. When treated with methylamine, it blocks binding of apoE to lipoprotein receptor-related protein (LRP).

Regulatory Status:	RUO - Research Use Only

Product Literature References

Cytotoxicity mechanism of α-MMC in normal liver cells through LRP1 mediated endocytosis and JNK activation: L. Wang, et al.; Toxicology 357, 33 (2016), Abstract;