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Imgenex公司表觀遺傳學(xué)研究工具：Dnmt與HDAC抗體

2011-10-5　　閱讀(4590)

Imgenex公司表觀遺傳學(xué)研究工具：Dnmt與HDAC抗體

Dnmt and HDAC Antibodies for Epigenetics
Cell Regulation & DNA Repair

Histonedeacetylases exert transciptional control through deacetylation of core histone proteins. DNA methyltransferases regulate gene expression through cytosine methylation –changes in methylation patterns have been linked with neoplasia development. As a recognized leader and tool provider for cell regulatory pathway analysis, IMGENEX provides a comprehensive choice of highly referenced, validated antibodies specific for HDACs and Dnmts. We are continuing to build upon our leading portfolio for studying cell regulation by introduction of new products including transcription factors, ChIP Kits, signaling molecules and other key biomarkers. Utilization of our Pathway Profiling expertise and products continues to enable advanced research in Cancer, Apoptosis, Stem Cell/Developmental Biology and Immune/Inflammation Signaling Pathways.

Applications:

• Western Blot
• IHC
• ChIP
• Flow Cytometry

HDAC Antibodies

HDAC-1	HDAC-6
HDAC-2 （Ab-394）	HDAC-7
HDAC-3	HDAC-7 （Ser155）
HDAC-4	HDAC-7 （Ser318）
HDAC-4 （Ab-632）	HDAC-7 （Ser448）
HDAC-4 （Ser632）	HDAC-8 （Ab-39）
HDAC-5	HDAC-8 （Ser39）
HDAC-5 （Ab-498）	HDAC-9
HDAC-5 （Ser498）

Dnmt Antibodies

Dnmt1	Dnmt3a
Dnmt2	Dnmt3b

Related Pathways

Transcription Factors

Apoptosis Detection Kits/pSIVA

NF-kB Pathway

Dnmt3a, IMG-268A

Expression of Dnmt3a in the nuclei of post-mitotic neurons in the olfactory epithelium （OE）. DNMT3a （red） is co-expressed with neuron-specific tubulin （green） throughout the development of the olfactory epithelium, using IMG-268A. （Data courtesy of A. Jane Roskams, University of British Columbia）.

HDAC-7 （Ser155）, IMG-612

Western blot analysis of phosphorylated HDAC-7 in （A） recombinant fusion protein containin a phosphorylated serine at position 155 and （B） fusion protein containing an unphosphorylated serine at position 155, using IMG-612 at 0.1 ug/ml.

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Imgenex公司表觀遺傳學(xué)研究工具：Dnmt與HDAC抗體

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